Identification and functional characterization of hyaluronic acid in degenerative joint diseases
نویسندگان
چکیده
منابع مشابه
Chondroprotective drugs in degenerative joint diseases.
Catabolic cytokine and anabolic growth factor pathways control destruction and repair in osteoarthritis (OA). A unidirectional TNF-alpha/IL-1-driven cytokine cascade disturbs the homeostasis of the extracellular matrix of articular cartilage in OA. Although chondrocytes in OA cartilage overexpress anabolic insulin-like growth factor (IGF) and its specific receptor (IGFRI) autocrine TNF-alpha re...
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Hyaluronic acid is the macromolecule which endows synovial fluid with its viscoelastic properties and it is often assumed these properties are important for the lubrication of the tissue surfaces in diarthrodial joints (Barnett, Davies, and MacConaill, 1961). The relationships, if any, that exist between the chemical and physical properties ofsynovial fluid and its lubricating ability, however,...
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Role of interleukin-7 in degenerative and inflammatory joint diseases
IL-7 is known foremost for its immunostimulatory capacities, including potent T cell-dependent catabolic effects on bone. In joint diseases like rheumatoid arthritis and osteoarthritis, IL-7, via immune activation, can induce joint destruction. Now it has been demonstrated that increased IL-7 levels are produced by human articular chondrocytes of older individuals and osteoarthritis patients. I...
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Trehalose is a non-reducing sugar that plays an important role in plant growth and development. To study the role of trehalose on lipid metabolism and gluconeogenesis, Arabidopsis thaliana wild type (WT) and TreF (a line expressing trehalase) were grown on ½ MS medium with or without 100 mM sucrose and or trehalose in light or continuous darkness. In dark, trehalose leads skotomorphoge...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.lb19-a